国际眼科杂志2006，Vol.6Issue(4)：745-747,3.
细胞周期依赖性激酶抑制剂P27,P21在人角膜上皮的表达研究
Cyclin dependent kinase inhibitor P27, P21 expressions in human corneal epithelium
张明昌 1张红旭1
作者信息
- 1. 430022,中国湖北省武汉市,华中科技大学同济医学院附属协和医院眼科
- 折叠
摘要
Abstract
AIM: To investigate the expressions of the cyclin dependent kinase inhibitor (CKI) in human corneal epithelium.METHODS: The expressions of CKI, P27, P21 and proliferating cell nuclear antigen (PCNA) were tested in different regions of corneal epithelium by SP immunohistochemistry.RESULTS: Limbal basal cells stained positively for PCNA while central corneal epithelium cells stained negatively for PCNA, their difference was statistically significant (P＜0.01).Positive staining for P27 and P21 were observed in central epithelium, but there was no positive staining in limbal epithelium. Their difference were also statistically significant (P＜0.01).CONCLUSION: The different expressions of CKI P27, P21and PCNA in different corneal epithelial regions suggest that in limbal basal layer there are a group of cells that have higher proliferative capacity staying in G1 status, namely stem cell.关键词
CKI/P27/P21/PCNA/角膜上皮干细胞Key words
cyclin dependent kinase inhibitor/P27/P21/proliferating cell nuclear antigen/corneal epithelial stem cells分类
医药卫生引用本文复制引用
张明昌,张红旭..细胞周期依赖性激酶抑制剂P27,P21在人角膜上皮的表达研究[J].国际眼科杂志,2006,6(4):745-747,3.
