中德临床肿瘤学杂志(英文版)2004，Vol.3Issue(2)：74-77,4.
血管内皮生长因子C在胃癌中的表达及其与淋巴结转移的关系
Vascular Endothelial Growth Factor C Expression in Gastric Carcinoma and Its Relationship with Lymph Node Metastasis
摘要
Abstract
Objective: To study the expression of vascular endothelial growth factor C (VEGF-C) in gastric carcinoma and its relationship with lymph node metastasis. Methods: The expression of VEGFC mRNA in 5 gastric carcinoma cell lines was detected by reverse transcription-polymerase chain reaction (RT-PCR).Simultaneously, the expression of VEGF-C protein in gastric carcinoma tissues, which were obtained from 63 patients who underwent radical gastrectomy, was detected by immunohistochemistry. Results: Three of the 5 gastric carcinoma cell lines, MKN-45, SGC-7901 and AGS, expressed VEGFC mRNA. VEGF-C protein was expressed in 52.4% (33/63) of patients. VEGF-C protein expression was more frequently found in tumors with lymph node metastasis than in those without (P＜0.01). VEGF-C protein expression was also closely related to lymphatic invasion (P＜0.01) and TNM stage (P＜0.01). However, there wasno significant correlation between VEGF-C expression and the age, gender, tumor size, tumor location,Lauren classification, depth of invasion and vascular invasion. Conclusion: The expression of VEGF-C is closely related to lymph node metastasis of gastric carcinoma, and lymphangiogenesis might be a new target for treatment of gastric carcinoma.关键词
胃癌/血管内皮生长因子/淋巴结转移/淋巴管生成Key words
Gastric carcinoma/vascular endothelial growth factor/lymph node metastasis/lymphangiogenesis分类
医药卫生引用本文复制引用
严超,林言箴,张俊,计骏,于颖彦,张奕,纪玉宝,刘炳亚,朱正纲,尹浩然..血管内皮生长因子C在胃癌中的表达及其与淋巴结转移的关系[J].中德临床肿瘤学杂志(英文版),2004,3(2):74-77,4.基金项目
This project was supported by a grant from Shanghai Bureau of Health (No. 983008). （No. 983008）
