高等学校化学学报2001，Vol.22Issue(5)：749-753,5.
镍离子注入修饰电极上米托蒽醌与DNA相互作用的电化学研究
Electrochemical Studies of Mitoxantrone Interaction with DNA at a Ni/GC Ion Implantation Modified Electrode
摘要
Abstract
The electrochemical behavior of mitoxantrone interaction with DNA at a Ni/GC modified electrode was studied by linear sweep and cyclic voltammetry. In 0.05 mol/L Tris-0.5mol/L NaCl solution (pH=7.1), the reaction of DNA with MX formed an electrochemically nonactive complex, resulting in a decrease in the MX equilibrium concentration and its reduction current. The composition of the complex was n(MX)∶n(DNA)=2∶1. The combining constant was 1.61×1012. The electrode reaction rate constant k0 and the electron transfer coefficient α were 0.33 s-1 and 0.41, respectively. The decrease in peak current was proportional to DNA concentration and can be used to determine DNA concentration.关键词
米托蒽醌/DNA/离子注入/修饰电极/电化学行为分类
化学化工引用本文复制引用
胡劲波,尚军,李启隆..镍离子注入修饰电极上米托蒽醌与DNA相互作用的电化学研究[J].高等学校化学学报,2001,22(5):749-753,5.基金项目
国家自然科学基金 （）
