血管内皮细胞生长因子受体2基因短发夹RNA介导基因沉默对白血病的抑制OA北大核心CSCDCSTPCD
Inhibition of leukemia mediated by vascular endothelial growth factor receptor 2 short hairpin RNA gene silencing
背景:血管内皮细胞生长因子受体2(vascular endothelial growth factor receptor 2,VEGFR2)在血管内皮细胞生长因子的信号转导中有主导效应,并在某些疾病包括白血病的病理性血管生成中起关键作用.另外,白血病细胞分泌的血管内皮细胞生长因子还诱导自身表达VEGFR2,从而维持自身存活、增殖.目的:观察表达VEGFR2短发夹RNA(short hairpin RNA,shRNA)的慢病毒载体Lenti6/sh…查看全部>>
BACKGROUND: Vascular endothelial growth factor receptor 2 (VEGFR2) is primarily involved in vascular endothelial growth factor (VEGF)-mediated signal transduction and plays a critical role in the pathological angiogenesis that occurs in a number of diseases, including leukemia. Besides, VEGF secreted by leukemia cells also induces its own expression which leads to an enhanced production of VEGFR2 which contributes to the survival and proliferation of leukemi…查看全部>>
郭海霞;徐令;陈月琴;李文益
中山大学附属第二医院,儿科,广东省广州市,5101202中山大学附属第二医院,医学研究中心,广东省广州市,510120中山大学附属第二医院,儿科,广东省广州市,5101202中山大学附属第二医院,医学研究中心,广东省广州市,510120
临床医学
血管内皮细胞生长因子受体2shRNA慢病毒白血病基因治疗
《中国组织工程研究与临床康复》 2007 (37)
7503-7508,6
Guangdong Science and Technology Program Fund, No.2006B36301003 广东省科技计划项目(2006B36301003)
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