第一军医大学学报2003，Vol.23Issue(8)：757-760,4.
子宫内膜异位症患者腹水与血清中肝细胞生长因子的检测
Determination of HGF concentration in serum and peritoneal fluid in women with endometriosis
宗利丽 1李亚里 2哈小琴3
作者信息
- 1. 第一军医大学珠江医院妇产科,广东,广州,510282
- 2. 北京长城医院妇产科,北京,100853
- 3. 北京放射医学研究所,北京,100039
- 折叠
摘要
Abstract
Scatter factor (hepatocyte growth factor, SF/HGF) is a multifunctional polypeptide growth factor that plays animportant role in tumor proliferation, angiogenesis and invasiveness. The aim of this study was to investigate the role of HGFin endometriosis and their relationship. Peritoneal fluid and serum samples of 126 women of reproductive age receivinglaparoscopy (72 with endometriosis and 54 without endometriosis) were obtained and enzyme-linked immunosorbent assay(ELISA) was employed to measure HGF concentrations. The results revealed that the concentrations of HGF were significantlyelevated in women with endometriosis stages Ⅰ/Ⅱ and Ⅲ/Ⅳas compared with HGF level in the control group (peritoneal fluidlevels of 0.337±0.065, 0.458±0.160, 0.915±0.113, P＜0.001; serum level of 0.335±0.663, 0.456±0.151, 0.907±0.170, P＜0.001respectively). A positive correlation was found between peritoneal fluid and serum levels of HGF, which varied little withphases of the menstrual cycle. Comparisons of the women in the same menstrual cycle between the three groups revealed thatincreased levels of HGF in patients with advanced endometriosis were not attributed to the cycle phase. Our results indicatedthat the degree of endometriosis was positively correlated with HGF concentration in peritoneal fluid and serum. Therefore,the detection of serum HGF concentration may be useful in classifying endometriosis, and may also help in selecting theoptimal treatment methods.关键词
子宫内膜异位症/肝细胞生长因子/腹水/血清Key words
endometriosis/hepatocyte growth factor/peritoneal fluid/serum分类
医药卫生引用本文复制引用
宗利丽,李亚里,哈小琴..子宫内膜异位症患者腹水与血清中肝细胞生长因子的检测[J].第一军医大学学报,2003,23(8):757-760,4.
