天然产物研究与开发2005，Vol.17Issue(6)：758-761,4.
两面针提取物(S-O)对小鼠镇痛、抗炎和止血作用的研究
The Effects of the Extract(S-O) from Zanthoxylum nitidum on Analgesia,Anti-inflammation and Hemostasia in Mice
刘绍华 1覃青云 1方堃 1唐献兰 1杨卫豪 1谢金鲜 2李爱媛 2周芳 2张祥民3
作者信息
- 1. 柳州两面针股份有限公司博士后工作站,柳州,545001
- 2. 广西中医学院药学院,南宁,530001
- 3. 复旦大学化学系,上海,200433
- 折叠
摘要
Abstract
The roots of Zanthoxylum nitidum(Rox. )DC have been commonly used for rheumatism arthritis,strain gall,neuralgia, toothache, stomach angina, and ulcer etc, in traditional Chinese medicine. This study was performed to assess the efficacies of the extract of the roots of Zanthoxylum nitidum(S-0) on analgesia, anti-inflammation and hemostasia in mice. Each efficacy was assessed by two methods. Analgesia was assessed by the methods of hot-plate and writhing test. In hot plate test, 150 mg/kg S-O has significantly increased the pain threshold of mice( P ＜ 0.01 ). In the writhing test, 150 mg/kg S-O, the number of writhes were reduced more than 70.96% (P ＜ 0.01 ). Anti-inflammation was assessed by the methods of xylene induced ear edema and vascular permeability augmentation by acetic acid test. In the xylene induced ear edema, the inhibition of 150 mg/kg S-O was 63.45 ( P ＜ 0.05). In the vascular permeability augmentation by acetic acid test, the inhibition of anti-inflammation of 150 mg/kg,75 mg/kg S-O were 52.94% ( P ＜0.05) ,52.00%( P ＜0.05),respectively,it has significant anti-inflammation.Hemostasia was assessed by the methods of glass tube and glass plate.In glass tube test,both doses of S-O (150 mg/kg, 75 mg/kg) can significantly prolong the blood solidification time ( P ＜ 0.01 ). In the glass plate test, 150 mg/kg S-O can also significantly prolong the blood solidification time( P ＜ 0.01). In conclusion, the S-O of Zanthoxylum nitidum has significant efficacies onanalgesia, anti-inflammation and hemostasia in mice.关键词
两面针/镇痛/抗炎/止血/提取物Key words
Zanthoxylum nitidum/analgesia/anti-inflammation/hemostasia/extract分类
医药卫生引用本文复制引用
刘绍华,覃青云,方堃,唐献兰,杨卫豪,谢金鲜,李爱媛,周芳,张祥民..两面针提取物(S-O)对小鼠镇痛、抗炎和止血作用的研究[J].天然产物研究与开发,2005,17(6):758-761,4.
