首页|期刊导航|中华医学杂志（英文版）|Effects of lactulose on intestinal endotoxin and bacterial translocation in cirrhotic rats
中华医学杂志（英文版）2003，Vol.116Issue(5)：767-771,5.
Effects of lactulose on intestinal endotoxin and bacterial translocation in cirrhotic rats
Effects of lactulose on intestinal endotoxin and bacterial translocation in cirrhotic rats
摘要
Abstract
Objective To investigate the effects of lactulose on intestinal bacterial overgrowth (IBO), bacterial translocation (BT), intestinal transit and permeability in cirrhotic rats. Methods BT in all animals was assessed by bacterial culture of mesenteric lymph node (MLN), liver and spleen, and IBO was assessed by a jejunal bacterial count of the specific organism. Intestinal permeability was determined by the 24-hour urinary 99mTc-diethylenetriaminepentaacetate (99mTc-DTPA) excretion, and intestinal transit was determined by measuring the distribution of 51 Cr in the intestine. Results BT and IBO were found in 48% and 80% of the cirrhotic rats, respectively, while not in the control rats. Cirrhotic rats with IBO had significantly higher levels of intestinal endotoxin higher rates of bacterial translocation, shorter intestinal transit time and higher intestinal permeability than those without IBO. It was also found that BT was closely associated with IBO and injury of the intestinal barrier. Compared with the placebo group, lactulose-treated rats had lower rates of BT and IBO, which was closely associated with increased intestinal transit and improved intestinal permeability by lactulose. Conclusions Our study indicate that endotoxin and bacterial translocation in cirrhotic rats may attribute to IBO and increased intestinal permeability. Lactulose that accelerates intestinal transit and improves intestinal permeability might be helpful in preventing intestinal bacterial and endotoxin translocation.关键词
bacterial translocation/cirrhosis/intestinal permeability/lactulose/endotoxinKey words
bacterial translocation/cirrhosis/intestinal permeability/lactulose/endotoxin分类
医药卫生引用本文复制引用
张顺财,王唯,任卫英,戴茜,贺伯明,周康..Effects of lactulose on intestinal endotoxin and bacterial translocation in cirrhotic rats[J].中华医学杂志（英文版）,2003,116(5):767-771,5.基金项目
This study was partially supported by the National Natural Science Fundation of China (No. 30070340). （No. 30070340）
