中国药理学通报2001，Vol.17Issue(1)：76-79,4.
糖皮质激素对下丘脑-垂体-肾上腺轴钙调素基因表达的影响
Effect of glucocorticoid on the calmodulin mRNA of
hypothalamus-pituitary-adrenal axis
宋春风 1尹桂山 1吕佩源 2孙素菊 1王桂香1
作者信息
- 1. 河北医科大学生物化学教研室,
- 2. 河北省人民医院神经内科,
- 折叠
摘要
Abstract
AIM To study the effect of glucocorticoid acetic acid cortisone on expression of CaM mRNA in hypothalamus-pituitary-adrenal axis (HPAA). METHODS Using reverse transcription polymerase chain reaction (RT-PCR),the expression of CaM mRNA was measured in HPAA of rats which were injected with acetic acid cortisone. RESULTS Acetic acid cortisone induced the expression of CaM mRNA in hypothalamus and adrenal respectively, but it had no effect significantly in pituitary. CONCLUSION These data suggest that CaM mRNA plays important role in the modulation of GC in HPAA.关键词
钙调素/基因/糖皮质激素/下丘脑/垂体/肾上腺分类
医药卫生引用本文复制引用
宋春风,尹桂山,吕佩源,孙素菊,王桂香..糖皮质激素对下丘脑-垂体-肾上腺轴钙调素基因表达的影响[J].中国药理学通报,2001,17(1):76-79,4.
