摘要
Abstract
Objective To investigate the factors related to curable resection and efficacy of pancreatic cancer. Methods A uniform questionnaire for national survey on clinical epidemiology of pancreatic cancer was designed by Committee of Pancreatic Cancer, CACA from January 1, 1990 to December 31, 2000. A total of 2340 cases were included. Survival analysis was conducted for selected cases with complete data. Cox regression was used to screen out single and multiple risk factors. Cumulative survival rate was calculated by life table and Gehan score test.Results COX single factor analysis revealed that significant variables at α=0.05 level included age, occupation, duration of disease, location of neoplasm, operation type, postoperative pancreatic fistula, postoperative hepatic failure, chemotherapy, TNM stage, immunotherapy, liver metastasis, invasion of superior mesenteric vessel. COX multifactor analysis demonstrated that significant variables at α=0.05 level were age, surgical procedures, postoperative pancreatic fistula, postoperative hepatic failure, chemotherapy, immunotherapy. These were independent factors for the prognosis of pancreas carcinoma. Among these factors, age less than 70 years, radical operation, chemotherapy and immunotherapy were all protective factors. 92.91% of the patients were more than 40 years of age. Only 7.09% of those were less than 40. The median survival time of group of radical resection of carcinoma in head of pancreas was 17.11 months and the 1-, 3-, 5-year survival rates were 54.36%, 13.47%, 8.47% respectively. Conclusion For early diagnosis, an effective way to screen population older than 40 years is really an effective way to detect patients early and promptly. And comprehensive therapy is conducive to better quality of life and longer survival time of pancreatic cancer.关键词
胰腺癌/诊断/外科/治疗/预后Key words
pancreatic cancer/diagnosis/surgery/therapy/prognosis分类
医药卫生
