中国现代医学杂志2007，Vol.17Issue(7)：769-772,4.
抗凋亡基因Bag-1和Bcl-2在结肠癌组织中的表达及其相互关系
Expression and relation of the anti-apoptotic gene Bag-1 and Bcl-2 in colon cancer
孙念峰 1陈景波 1王国斌1
作者信息
- 1. 华中科技大学同济医学院附属协和医院,普外科,湖北,武汉,430022
- 折叠
摘要
Abstract
[Objective] To investigate the expression and significance of anti-apoptotic gene Bag-1 and Bcl-2 in colon cancer, and evaluate their relation. [Methods] The expression of the Bag-1 and Bcl-2 in 64 colon cancer tissue and 10 normal colon tissue samples was examined by immunohistochemical technique (sptreptavidin-biotin-peroxidase complex method). [Result] The expression of Bag-1 in colon cancer was closely correlated with pathologic grade, distante metastasis, Dukes stage and prognosis had no effect on the pathologic type, tumor diameter.depth of invasion and lymphoid node metastasis of the cancer. However, Bcl-2 had no significant correlation with all these clinical and pathologic factors. We also found that there was a positive correlation between Bag-1 and Bcl-2 in the developing progress of the colon cancer. [Conclusion] There is high expression of Bag-1 and Bcl-2 protein in colon cancer. They might be regarded as a biomarker for the diagnosis of early period colon cancer, and have significant meaning for the prognosis of colon cancer.关键词
大肠癌/Bag-1/Bcl-2/细胞凋亡Key words
colon cancer/Bag-1/Bcl-2/apoptosis分类
医药卫生引用本文复制引用
孙念峰,陈景波,王国斌..抗凋亡基因Bag-1和Bcl-2在结肠癌组织中的表达及其相互关系[J].中国现代医学杂志,2007,17(7):769-772,4.
