中国现代医学杂志2007，Vol.17Issue(7)：773-776,781,5.
生长激素对梗阻性黄疸肝细胞免疫功能影响的实验研究
Somatotrophin promotes hepatic immune modulation in obstructive jaundice: an experimental investigation
王勇 1刘金钢 1余云1
作者信息
- 1. 中国医科大学附属第二医院,肝胆外科,辽宁,沈阳,110004
- 折叠
摘要
Abstract
[Objective] To investigate proliferative cell nuclear antigen and intercellular adhesive molecular-1 expression in rat liver cells suffered from common bile duct ligation, whether somatotrophin has modulating effect on promoting hepatocyte immune modulation. [Methods] Obstructive jaundice model was used in this experiment. In the model rat's common bile duct was double-ligated. Serum endotoxin, bilirubin, and albumin were measured with HITACHI automatic biochemistry analyzer. Hepatic ICAM-1 and PCNA analysis were detected and analyzed to compare with immune injury. [Results] Serum endotoxin level in OJ group was (0.77±0.03)u. The values of T-BIL,D-BIL,ALB and GPT in OJ group were (186.64±49.59)μmol/L,(144.64±41.09)μmol/L,(18.77±2.01)g/L and (180.42±30.88)u/L. In somatotrophin group they were (150.51± 24.28)μmol/L, (104.98±16.10)μmol/L, (23.43±2.76)g/L and (125.69±29.61) u/L. ICAM-1 and PCNA expression analysis in two groups showed what in somatotrophin group was better. [Conclusions] In obstructive jaundice endotoxin could hurt hepatocyte and hepatic function. On the other side somatotrophin could recover hepatocyte function and eliminate hepatic injury.关键词
生长激素/免疫调节/梗阻性黄疸/细胞间粘附分子-1/增生细胞核抗原Key words
somatotrophin/immune modulation/obstructive jaundice/intercellular adhesive molecular-l/proliferative cellular nuclear antigen分类
医药卫生引用本文复制引用
王勇,刘金钢,余云..生长激素对梗阻性黄疸肝细胞免疫功能影响的实验研究[J].中国现代医学杂志,2007,17(7):773-776,781,5.
