咸宁医学院学报2001，Vol.15Issue(2)：77-79,3.
辣椒素急性脱敏治疗三叉神经痛的实验研究
An Experimental Study of Acute Desensitization with Capsicin to Treat the Prosopalgia
丁继固 1关春保 2林传友 3殷光甫 3茹立强3
作者信息
- 1. 咸宁医学院解剖学教研室,
- 2. 深圳市宝安区观澜医院,
- 3. 华中科技大学同济医学院神经生物学研究室,
- 折叠
摘要
Abstract
Objective According to analgesic mechanism of the capsicin(CAP),to research its acute desensitizing(analgesic) effect on prosopalgia.Methed A 30mM-solution of capsicin was prepared for subcutaneous injection at infraorbital region to infiltrate trigeminal nerve-branch.The volume of solution injected at a time for each rat was 20μl(group A),30μl(group B),50μl(group C)and 100μl (group D) respectively.Using“Heat pain checker”to measure pain threshold in the different time,and to observe the changes of rat's behavior.Results The time spending to obtaining desencitization for each group was as follows:group A—72－120 hrs,B—12－24 hrs,C—8－12 hrs and D—2－4hrs.When the desencitization was derived,a maintence-administration of CAP was made with an interval of 24,48,72 and 96 hrs for group A,B,C and D respectively,and it should be carry on until the total dosage was equal to 50mg/kg.It showed that there was not notable difference among the recovering rate of all groups(X 0.122 of each group).Conclusion CAP-infiltration at infraorbital region in rat can produce strong analgesic effect.关键词
辣椒素/三叉神经痛/急性脱敏/大鼠分类
医药卫生引用本文复制引用
丁继固,关春保,林传友,殷光甫,茹立强..辣椒素急性脱敏治疗三叉神经痛的实验研究[J].咸宁医学院学报,2001,15(2):77-79,3.
