解剖学杂志2001，Vol.24Issue(1)：77-81,5.
实验性变态反应性脑脊髓炎大鼠模型的建立
ESTABLISHING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS MODEL IN RATS
曹翠丽 1王惠 1马常升 1杨天祝1
作者信息
- 1. 河北医科大学基础医学研究所神经生物研究室，石家庄050017
- 折叠
摘要
Abstract
Objective: To establish a reliable and simple method for establishing the experimental allergic encephalomyelitis(EAE) in rats. Methods: Immune antigen was made from both self-made complete Freund adjuvant and spinal cord homogenate of guinea pig, and were injected into rats' paw-pads. Results: On day 12～ 18, rats were paralyzed on its 2 hind limbs, the coronal sections of lumbosacral enlargement of spinal cord with HE stainning showed that there were dilated capillaries, perivascular oversleeve-like inflammatory infilltration and anterior-horn motor-neuron hydropic degeneration.Conclusion: The method is easy to manipulate and reproduce, and is suitable for wide application.关键词
实验性变态反应性脑脊髓炎/动物模型/大鼠Key words
experimental allergic encephalomyelitis/ animal model/ rat分类
医药卫生引用本文复制引用
曹翠丽,王惠,马常升,杨天祝..实验性变态反应性脑脊髓炎大鼠模型的建立[J].解剖学杂志,2001,24(1):77-81,5.
