中国临床康复2004，Vol.8Issue(4)：788-789,2.
胶质细胞源性神经营养因子对脊髓前角运动神经元的保护作用
Protective reaction of glial cell line-derived neurotrophic factor to anterior cornual motoneuron
摘要
Abstract
AIM: To verify the protective reaction of glial cell line-derived neruotrophicfactor(GDNF) to anterior cornual motoneuron.METHODS: Anterior cornual motoneuron injury model was established bydisjunction one side of sciatic nerve in SD rat. GDNF was provided locally atneuron focal area by dint of mono-cecum silicon vessel system. L5 spinal cordslice was taken at different time after surgery. The activities of Choline es-terase and acid phosphatase(ACP) was displayed by enzymic histochemicalcoloring method and analyzed through image assay.RESULTS: On the 4th, 9th, 16th, and 21st day after the disjunction of sci-atic nerve, the activities of choline esterase in control and GDNF groups were21.53+1.54 and 23.67+1.08 respectively(P ＜ 0.05), 19.82+1.35and 22.87+1.04(P ＜ 0.01), 22.55+1.20 and 25.25+1.13(P ＜0.01 ), and 25.52 + 1.43 and 28.92 + 1.37 ( P ＜ 0.01 ) respectively. ACPactivities(mean gray, MG) in control and GDNF groups were 37.49 + 1.39and 35.40±1.18(P ＜ 0.05), 40.94+1.38 and 38.43+1.31(P ＜0.05), 22.55 +1.20 and 25.25+1.13(P ＜0.05), and 37.15 ±1.52and 34.68 ± 1.43 ( P ＜ 0.05 ) respectively.CONCLUSION: GDFN has protective reactions to anterior cornual mo-toneuron injury.关键词
神经生长因子类/坐骨神经/脊髓/运动神经元/创伤和损伤分类
医药卫生引用本文复制引用
宋海涛,贾连顺,田万成,陈哲宇,何成..胶质细胞源性神经营养因子对脊髓前角运动神经元的保护作用[J].中国临床康复,2004,8(4):788-789,2.基金项目
国家自然科学基金资助项目(39500044) （39500044）
