中华医学杂志（英文版）2001，Vol.114Issue(8)：791-794,4.
外源性呼气末正压对慢性阻塞性肺疾病患者呼吸功的影响
Effects of extrinsic positive end-expiratory pressure on work of breathing
in patients with chronic obstructive pulmonary disease
孔维民 1王辰 1杨媛华 1黄克武 1姜超美1
作者信息
- 1. 首都医科大学附属北京朝阳医院北京市呼吸病研究所北京 100020
- 折叠
摘要
Abstract
Objective To investigate the effects of extrinsic positive end-expiratory pressure (PEEPe) on work of breathing in patients with chronic obstructive pulmonary disease (COPD) and their corresponding mechanism.
Methods Ten ventilated patients with COPD were included in the study. A Bicore CP-100 pulmonary monitor （Bicore Monitoring System, USA） was used for monitoring respiratory mechanics. First, dynamic intrinsic positive end-expiratory pressure (PEEPi,dyn) was measured when PEEPe was zero, which was called PEEPi,dynz. Then the PEEPe was set randomly at 0%, 40%, 60%, 80% and 100% of PEEPi,dynz respectively. Pulmonary mechanics and other parameters (heart rate, blood pressure and blood gas analysis) were measured 30 minutes after the level of PEEPe was changed.
Results Work of breathing patient (WOBp), pressure time product, difference of esophageal pressure and PEEPi,dyn decreased significantly when PEEPe was applied, and continued decreasing as PEEPe was increased. Work of breathing ventilator increased significantly when PEEPe was increased to 80% and 100% of PEEPi,dynz. Significantly positive linear correlation was found between the changes in WOBp and in PEEPi,dyn.
Conclusions WOBp decreases gradually as PEEPe is increased. WOBp decreases by narrowing the difference between the alveolus pressure and the central airway pressure at the end of expiration when PEEPe is applied.关键词
阻塞性肺疾病/外源性呼气末正压/内源性呼气末正压/呼吸功Key words
obstructive pulmonary disease/mechanical ventilation/extrinsic positive end-expiratory pressure/work of breathing分类
医药卫生引用本文复制引用
孔维民,王辰,杨媛华,黄克武,姜超美..外源性呼气末正压对慢性阻塞性肺疾病患者呼吸功的影响[J].中华医学杂志（英文版）,2001,114(8):791-794,4.
