现代妇产科进展2008，Vol.17Issue(10)：797-800,4.
PTEN coding product:a new marker for tumorigenesis and progession of endometrial carcinoma
PTEN coding product:a new marker for tumorigenesis and progession of endometrial carcinoma
摘要
Abstract
Objective :To investigate the expression of PTEN in carcinogenesis and development of endometrial carcinoma.Methods: The expression of PTEN was detected by reverse transcription-polymerase chain reaction(RT-PCR) methods from 24 cases with endometrial carcinoma,10 cases with endometrial atypical hyperplasia,I0 eases with endometrial hyperplasia and I0 cases with normal endometrium and by SP immunohistochemical methods from 73 cases with endometrial carcinoma,25 cases with endometrial atypical hyperplasia,71 cases with endometrial hyperplasia and 31 cases with normal endometrium.Results:PTEN expression of both RNA and protein in patients with endometrial carcinoma and endometrial atypical hyperplasia was significantly lower than that of patients with endometrial hyperplasia and normal endometriurn.mRNA relative value was 0.35±0.13,0.46±0.11,2.32±0.32,2.45±0.51,respectively.Loss of PTEN expression rates were 66.67% (38/57) ,76.00% ( 19/25 ) ,5.63% (4/71 ) ,0 (0/31 ),repeetively.The results were also compared with clinical parameters.Loss of PTEN expression in patients with endometrial carcinoma was significantly related to histological classification ( P ＜ 0.0001 ) and differentiation ( P ＜ 0.05 ).It was not related to depth of myometrium invasion and clinical stage( P ＞0.05 ).Conclusion:Loss of PTEN expression is an early event in endometrial tumorigenesis.Detection of PTEN protein may be a diagnostic biomarker for endometrial precancers and adenocareinoma.关键词
Endometrial neoplasm/PTEN/ImmanohistochemistryKey words
Endometrial neoplasm/PTEN/Immanohistochemistry分类
医药卫生引用本文复制引用
Gao Qinglei,Li Jing,Xing Hui,Lu Yunping,Zhou Jianfeng,Ma Ding..PTEN coding product:a new marker for tumorigenesis and progession of endometrial carcinoma[J].现代妇产科进展,2008,17(10):797-800,4.基金项目
This project was supported by the grants from 973 National Great Foundation Research Program of China ( No:2002CB513100)and National Natural Science Foundation of China( No :30600667 ) （ No:2002CB513100）
