中国免疫学杂志2001，Vol.17Issue(2)：79-81,3.
CEA重组痘苗病毒免疫治疗CEA阳性肿瘤机制的研究
A study of the mechanism of the effect of a recombinant vaccinia virus expressin g human cartcinoembryonic antigen on CEA positive tumor
赵青 1陶莎 2杨洁 2罗超权2
作者信息
- 1. 广州医学院羰生教研室工作,
- 2. 中山医科大学生物化学教研室,
- 折叠
摘要
Abstract
Objective:To explore antitumor mechanism of a re combinant vaccinia virus expressing human carcinomembryonic antigen(rV-CEA).[ WT5”HZ Methods:C57bl/6 mice were immu nized three times with rV-CEA.Six weeks later,the splenocytes from rV-CEA-imm unized donors were adoptively tranfered in sublethally irradiated CEA+-HePa- bearing recipients,meanwhile the antiumor effect of the donor splencytes in virt ro was detected.Results:Splenocytes from rV-CEA-immunize d donors expressed strong antiumor activity in CEA positive tumorbearing recipie nts,whereas W-VV-immunized and nonimmune donor cell did not.The antiumor acti vity was abolished when immune T cells were depleted before splencytes transfer.Conclusion:It was demonstrated that antiumor acivity induc ed by rV-CEA was essentially mediated by immune T cells which were activated by CEA-specific immune response.Adoptive immunotherapy strategies may have implic a tions for both the study of rV-CEA and the development of potential clinical a pplications for tumor immunotherapy.关键词
癌胚抗原 重组痘苗病毒 过继免疫治疗 CEA阳性肿瘤分类
医药卫生引用本文复制引用
赵青,陶莎,杨洁,罗超权..CEA重组痘苗病毒免疫治疗CEA阳性肿瘤机制的研究[J].中国免疫学杂志,2001,17(2):79-81,3.
