山西医科大学学报2001，Vol.32Issue(z1)：79-82,4.
抗心脏β1和M2受体自身抗体与老年扩张型心肌病
Autoantibodies against the myocardial β1-adrenergic and M2-musca rinic receptors in patients with aged dilated cardiomyopathy
张麟 1胡大一 1史旭波 1李静1
作者信息
- 1. 首都医科大学心血管病研究所附属北京朝阳医院心脏中心,
- 折叠
摘要
Abstract
Objective To determine whether the autoan tibodies against β1-adrenergic and M2-muscarinic receptors are related to patients with elder dilated cardiomyopathy(EDCM).Methods Both synthetic pe ptides corresponding to amino acid sequences 197-222 and 169-173 of the second e xtracellular loops of the β1 and M2 receptors were used as the antigens to screen the serum from the patients with EDCM(n=32); Meanwhile the healthy bl ood donors were as the normal control group (NC, n=20). Results The pos itive sera for β1-adrenergic receptor were made up of 37.5% (12/32) and 5.0% ( 1/20) in EDCM patients and NC group respectively (P<0.05); The positive sera for M2-muscarinic receptor were made up of 40.6% (13/32) and 10.0%(2/20) in EDCM patients and NC group (P<0.05). The frequencies of the both receptor au toantibodies in patients with cardiac function class II-III were 2 times higher than those with cardiac function class IV.Conclusion These findings indicat e that autoantibodies against β1-adrene-receptor and M2-muscarinic recep tors are related to EDCM. It is suspected that autoantibodies against β1 and M2 receptors may play a role in the pathogenesis and myocardial remodeling of EDCM.关键词
心肌病,充血性/受体,肾上腺素能β/受 体,毒蕈碱/老年人分类
医药卫生引用本文复制引用
张麟,胡大一,史旭波,李静..抗心脏β1和M2受体自身抗体与老年扩张型心肌病[J].山西医科大学学报,2001,32(z1):79-82,4.
