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首页|期刊导航|南京医科大学学报(英文版)|Study of the immunoisolating effects of barium-alginate microencapsulation on rat islets allograft survival

Study of the immunoisolating effects of barium-alginate microencapsulation on rat islets allograft survival

Mei Zhang Chao Liu Cuiping Liu Youwen Qin Zhaosun Zhen

南京医科大学学报(英文版)2005,Vol.19Issue(2):81-85,5.
南京医科大学学报(英文版)2005,Vol.19Issue(2):81-85,5.

Study of the immunoisolating effects of barium-alginate microencapsulation on rat islets allograft survival

Study of the immunoisolating effects of barium-alginate microencapsulation on rat islets allograft survival

Mei Zhang 1Chao Liu 1Cuiping Liu 1Youwen Qin 1Zhaosun Zhen1

作者信息

  • 1. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • 折叠

摘要

Abstract

Objective: To evaluate the immunoisolating effects of barium-alginate microencapsulation on islets allograft survival. Methods: The nonmicroencapsulated and microencapsulated islets were transplanted under the kidney capsule or intraperitoneally into Wistar rat with STZ-induced diabetes. The blood glucose and insulin secretion of grafts were observed. Graft function was tested by oral rats was associated with normal glucose and insulin profiles in response to OGTT. Conclusion: Microencapsulation with barium-alginate membrane can prolong islet survival and protect islets against allorejection.

关键词

allogeneic transplantation/immunoisolation/microencapsulation/islets/rat

Key words

allogeneic transplantation/immunoisolation/microencapsulation/islets/rat

引用本文复制引用

Mei Zhang,Chao Liu,Cuiping Liu,Youwen Qin,Zhaosun Zhen..Study of the immunoisolating effects of barium-alginate microencapsulation on rat islets allograft survival[J].南京医科大学学报(英文版),2005,19(2):81-85,5.

基金项目

Key Subject of Jiangsu Province 135 Projects (2001-31) (2001-31)

南京医科大学学报(英文版)

1674-8301

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