华西医科大学学报2001，Vol.32Issue(1)：83-85,3.
原发性肾病综合征患者外周血淋巴细胞亚群、白介素2及其高亲和力受体表达的研究
Lymphocyte Subpopulation, Interleukin-2 and High Affinity Interleukin-2 Receptor Expression in Primary Nephrotic Syndrome
摘要
Abstract
Objective To understand the cellular immune response duringrelapse and remission stage in primary nephrotic syndrome(PNS). Methods We applied the radioligand binding assay (RBA),the bioactivity measurement of IL-2,and monoclonal antibody sensitized red blood cell method to evaluate the expression of IL-2R, the production of IL-2 and T lymphocyte subsets of PBMC from 22 patients suffering from PNS, 17 patients with PNS in remission, and 25 normal subjects matched age and sex. Results CD3,CD4,CD8,IL-2,IL-2R in relapse were significantly lower than those in control (P<0.05); all above except CD8 in remission patients were significantly higher than those in relapse, but lower than those in control (P<0.05).Conclusion This study suggested that the cell mediated immunity (CMI) during acute nephrotic phase decreased; the deficiency of CMI of PNS in remission improved a lot when compared with the acute phase, but still not recovered completely; the deficiency of CMI with PNS in remission might be one of the causes of easily recurring of PNS.关键词
原发性肾病综合征/细胞免疫/白介素2/高亲和力白介素2受体分类
医药卫生引用本文复制引用
付平,许国章,黄颂敏,余庭龙..原发性肾病综合征患者外周血淋巴细胞亚群、白介素2及其高亲和力受体表达的研究[J].华西医科大学学报,2001,32(1):83-85,3.
