北京师范大学学报（自然科学版）2001，Vol.37Issue(1)：83-86,4.
多巴胺D2受体配体的合成及99mTc标记(Ⅰ) ——悬挂式设计
SYNTHESIS AND LABELING OF 99mTc-LABELED BENZAMIDE DOPAMINE D2 RECEPTOR IMAGING AGENTS (Ⅰ) ——EXPANDING DESIGN METHOD
摘要
Abstract
In developing 99mTc-labeled dopamine D2 receptor imaging agents,a new substituted benzamide compound is designed and synthesized. By tetering a S3 chelate system onto it, a technetium 3+1 complex is formed.Initial synthesis and radiolabeling suggest that the 99mTc complex is neutral and lipophilic.The factors which have influence on labeling yield are optimized, including pH value, ligand quantity, reaction temperature and time. Labeling yield is over 85%.关键词
多巴胺D2受体/配体交换/苯酰胺/99mTc标记化合物分类
化学化工引用本文复制引用
贾芳,刘正浩,唐志刚,张小波,刘伯里..多巴胺D2受体配体的合成及99mTc标记(Ⅰ) ——悬挂式设计[J].北京师范大学学报（自然科学版）,2001,37(1):83-86,4.基金项目
国家自然科学基金资助项目(29731020) （29731020）
