天然产物研究与开发2008，Vol.20Issue(5)：839-841,3.
金叶子中抑制膜结合型PGE2合酶-1表达活性物质的分离与鉴定
Isolation and Identification of mPGES-1 Expression Inhibitor from Craibiodendron yunnanense
摘要
Abstract
In the course of searching for anti-inflammatory agents from natural products,three known compounds were i-selated from the ethanol extract of the leaves of Craibiodendron yunnanense W. W. Smith and identified as quercetin (1) ,quercetin 3-O-α-L-arabinopyranoside (guaijaverin,2), quercetin 3-O-α-L-rhamnopyrancside (quercitrin,3). Com-pound 2 was isolated for the first time from this plant. Among these compounds,compound 1 showed significant bioactivi-ty against mPGES-1 expression with IC50 value of 35.40μg/mL.关键词
金叶子/膜结合型PGE2合酶-1/类风湿性关节炎/槲皮素/番石榴苷/栎素Key words
Craibiodendron yunnanense/mPGES-1/rheumatoid arthritis/Quercetin/Guaijaverin/Quercitrin分类
医药卫生引用本文复制引用
郭雷,龚邦强..金叶子中抑制膜结合型PGE2合酶-1表达活性物质的分离与鉴定[J].天然产物研究与开发,2008,20(5):839-841,3.基金项目
This work was supported by Natural Sciences Fund of Huaihai Institute of Technology. （）
