中国临床康复2004，Vol.8Issue(36)：8402-8403,2.
甲状腺功能亢进症合并骨质疏松患者生长激素变化的研究
Alteration of growth hormone in hyperthyroids with osteoporosis
张云良 1张润兰 2郭淑琴 1王君 1李志红 1吴继红 1席永昌 1张耐茹 1周秀英1
作者信息
- 1. 保定市第一中心医院内分泌科,河北省,保定市,071000
- 2. 石家庄铁路分局保定铁路医院内2科,河北省,石家庄市,071000
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摘要
Abstract
BACKGROUND: Hyperthyroidism and its induced osteoporosis gradually increase every year. To study the alteration of growth hormone in vivo at this period is good for the further understanding of the mechanism of its pathophysiological changes.OBJECTIVE: To comprehend the alteration of serous growth hormone in hyperthyroids with osteoporosis and the impacts of the correlative factors like thyroid level, age and the course of the disease on the loss of bone quantity.DESIGN: A case analysis. SSETTING: Department of Endocrinology, Boding First Central Hospital of Hebei Province.PARTICIPANTS: The study was performed in the Department of Endocrinology, Boding First Central Hospital of Hebei Province. Totally 146 hyperthyroids diagnosed for the first time were selected from the outpatient and inpatient departments of our hospital from Oetober 1999 to September 2000. According to their bone mineral density(BMD), the hyperthyroids were divided into normal group( n = 44), low-BMD group( n = 78) and osteoporosis group( n=24) based on bone mineral density(BMD).INTERVENTIONS: Pasting venous blood was collected from elbow vein for the detection of concentrations of growth hormone(GH), calcium(Ca), alkaline phosphatase (ALP), triiodothyronine (T3) and tetraiodothyronine ( T4 )with the reagent of the same batch. The eonelation among the above variants was analyzed by linear correlation analysis and the differences among the three groups were compared as well.among the three groups.RESULTS: There were very significant negative correlations among GH, ALP and BMD( r = -0. 456, P ＜ 0. 001) . GH had no significant correlations with age, course of disease, T3 and T4( r = 0. 005 to 0. 119, P ＞ 0. 10) .BMD of the neck, ward' s and G. T. parts were significantly negatively correlated with T3, T4 and the course of disease ( r = - 0.212 to - 0. 165 ) ( P＜ 0.05), while the BMD of L2 -4 was not correlated with the above three indices( r = 0. 010 to 0. 115, P ＞ 0. 10).CONCLUSION: The serous level of GH in hyperthyroids with osteoporosis elevates with the reduction of BMD. Lumbar BMD is relatively less affected by T3, T4 and the course of hyperthyroidism but closely related with the increase of age. The decrease of hipbone BMD is relatively obvious, which reminds the prevention of hipbone fracture in hyperthyroids.关键词
甲状腺功能亢进症/骨密度/促生长素/碱性磷酸酶分类
医药卫生引用本文复制引用
张云良,张润兰,郭淑琴,王君,李志红,吴继红,席永昌,张耐茹,周秀英..甲状腺功能亢进症合并骨质疏松患者生长激素变化的研究[J].中国临床康复,2004,8(36):8402-8403,2.
