首页|期刊导航|中华医学杂志（英文版）|Single fiber electromyography in the diagnosis of ocular myasthenia gravis:report of 90 cases
中华医学杂志（英文版）2004，Vol.117Issue(6)：848-851,4.
Single fiber electromyography in the diagnosis of ocular myasthenia gravis:report of 90 cases
Single fiber electromyography in the diagnosis of ocular myasthenia gravis:report of 90 cases
摘要
Abstract
Background The aim of this study was to evaluate single fiber electromyography (SFEMG) in the diagnosis of ocular myasthenia gravis (OMG), compared with repetitive nerve stimulation (RNS) and blood concentration of antibody to acetylcholine receptor (AchRAb).Methods SFEMG, RNS and AchRAb titration were measured in 90 patients with OMG (44 men, 46 women). Results Markedly increased jitter and ratio of block in the frontalis and the extensor digitorum communis (EDC) were observed (83.3% and 61.1%, respectively). The mean jitter was 43.6±14.5 μs, and the percentages of jitter>55 μs and blocking were 16.9%±19% and 3.5%±9.5% respectively in the EDC. The mean jitter was 64.3±25.6 μs, and the percentages of jitter >55 μs and blocking were 33.5%±27.6% and 29.3%±23.2% respectively in the frontalis. The percentage of abnormal RNS was 27.8% (25/90). There was an increased AchRAb titration in 29 (32.2%) of the 90 patients. Increased jitter, blocking was negatively correlated with maximum decrement to RNS (P<0.01). 11.4% (4/35) of patients with abnormal RNS and 24.1% (7/29) patients with abnormal AchRAb were seen in the patients with normal SFEMG in the EDC.Conclusion SFEMG test showed the highest sensitivity in the diagnosis of OMG. To our knowledge, the three methods (SFEMG, RNS and AchRAb) are complementary in the diagnosis and differential diagnosis of OMG.关键词
ocular myasthenia gravis/single fiber electromyography/repetitive nerve stimulationKey words
ocular myasthenia gravis/single fiber electromyography/repetitive nerve stimulation分类
医药卫生引用本文复制引用
崔丽英,管宇宙,王含,汤晓芙..Single fiber electromyography in the diagnosis of ocular myasthenia gravis:report of 90 cases[J].中华医学杂志（英文版）,2004,117(6):848-851,4.基金项目
This study was Supported by the Young Scientists Foundation of the Chinese Academy of Medical Sciences, China(973007) （973007）
