南京医科大学学报(英文版)2002，Vol.16Issue(2)：85-87,3.
The Antiandrogen Withdrawal Syndrome
The Antiandrogen Withdrawal Syndrome
华立新 1吴宏飞 1眭元庚 1程双管 1徐正铨 1张炜 1钱立新1
作者信息
- 1. Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,P. R. China
- 折叠
摘要
Abstract
Objective To evaluate the response to antiandrogen withdrawal in patients with advanced prostate cancer treated with combined androgen blockade. Methods Twenty-four cases of advanced prostate cancer (10 in stage C and 14 in stage D) were retrospectively studied. All the patients were treated with combined androgen blockade (bilateral orchiectomy and flutamide ). After initial response to hormone therapy for 7 to 36 months, flutamide was discontinued because of deterioration of the disease. Serum prostate specific antigen ( PSA ) levels were checked every 2 to 4 weeks and symptoms observed. Results The results following withdrawal of flutamide were as follows: 8 patients showed a decline in PSA (mean 7 4. 8 o% ), of whom 6 cases had the PSA decline greater than 5 0 %. Clinical symptoms improved in 4 cases. The nodules of the prostate were smaller than before in cases. The mean duration of response was 4. 3 months. Conclusion In patients with hormone refractory advanced prostate cancer after initial combined androgen blockade therapy, a trial of "antiendrogen withdrawal" is a reasonable choice of therapeutic maneuver.关键词
Prostate cancer/Prostate specific antigen/Antiandrogen withdrawalKey words
Prostate cancer/Prostate specific antigen/Antiandrogen withdrawal分类
医药卫生引用本文复制引用
华立新,吴宏飞,眭元庚,程双管,徐正铨,张炜,钱立新..The Antiandrogen Withdrawal Syndrome[J].南京医科大学学报(英文版),2002,16(2):85-87,3.
