中国药理学通报2001，Vol.17Issue(1)：86-88,3.
培菲康对硫代乙酰胺诱导的大鼠肝性脑病的保护作用
The effect of bifico on rat experimental hepatic encephalopathy induced by thioaetamide
田建锋 1李晓玉 1刘建华 1孙溢 1许建一 1陆小敏1
作者信息
- 1. 中国科学院上海生命科学院,上海药物研究所,
- 折叠
摘要
Abstract
AIM The effect of bifico on experimental hepatic encephalopathy (HE) induced by thioacetamide(TAA) and the possible mechanism of its protective effect were studied. METHODS Experimental hepatic encephalopathy was induced by ig thioacetamide 250 mg*kg-1 successively for two days; bifico was administraed ig once per day for one week before HE induction. RESULTS Compared with control HE rat, Bifico improved rat neuro-reflexes score and hepatic injury grade(P<0.05); thus decreased rat serum ammonium and LPS concentrations, respectively (P<0.05,P<0.01). The preparation slightly increased the ratio of chain amino acid to aromatic amino acid as well as reduced the degree of liver necrosis. CONCLUSION At the dosage of 840 mg*kg-1 ig for one week before liver intoxication, Bifico significantly protects rats from hepatic encephalopathy induced by TAA.关键词
培菲康/肝性脑病/硫代乙酰胺/血氨/LPS分类
医药卫生引用本文复制引用
田建锋,李晓玉,刘建华,孙溢,许建一,陆小敏..培菲康对硫代乙酰胺诱导的大鼠肝性脑病的保护作用[J].中国药理学通报,2001,17(1):86-88,3.
