华西口腔医学杂志2001，Vol.19Issue(2)：86-88,3.
流动剪切力作用下原代大鼠成骨样细胞PGE2的表达
Effects of Fluid Shear Stress on PGE2 Synthesis of Primary Osteoblast-like Cells in Rats
摘要
Abstract
Objective:The purpose of this study is to study the function of PGE2 during the signal transduction in which fluid shear stress regulates the proliferation and differentiation of osteoblast_like cells.Methods: The isolated rat primary osteoblast_like cells were exposed to fluid shear stress 0.12 mN/cm2 for 5, 10, 15, 30, 60 and 120 minutes respectively in a flow chamber. The release of PGE2 was examined. Results: After exposure to fluid shear stress, the PGE2 synthesis of rat primary osteoblast-like cells increased significantly (P<0.01) when compared with the control. After 10 minutes, the release of PGE2 began to increase significantly (P<0.01) and the effect was maximal after 60 minutes (P<0.01).Conclusion: PGE2 pathway may be one of the signal_transduction pathways which can transduce the fluid shear stress into osteoblast_like cells and then stimulate the bone remodeling.关键词
流动剪切力 成骨样细胞 PGE2 信号转导分类
医药卫生引用本文复制引用
乔鞠,陈伟辉,李声伟,罗颂椒,田卫东,张敏,李强..流动剪切力作用下原代大鼠成骨样细胞PGE2的表达[J].华西口腔医学杂志,2001,19(2):86-88,3.基金项目
本课题为国家自然科学基金资助项目(编号 39600167) （编号 39600167）
