中国组织工程研究与临床康复2008，Vol.12Issue(44)：8775-8778,4.
射频深部热疗中金属支架对猪食管黏膜的损伤
Damage to pig esophageal mucosa caused by metal stent in radiofrequency hyperthermia
陈玉林 1吴敬波 2宿向东 1谭燕琼 2范娟 2文庆莲 2黄镇东1
作者信息
- 1. 乐山市人民医院肿瘤科,四川省乐山市614000
- 2. 泸州医学院附属医院肿瘤科,四川省泸州市646000
- 折叠
摘要
Abstract
BACKGROUND: Thermotherapy has achieved remarkable therapeutic effect on patients with esophageal cancer. However, there are still some problems which cannot be answered today, such as the damage of esophageal mucosa during deep thermotherapy when metal stent is placed in esophagus. OBJECTIVE: To study the metal stent-caused damages to esophageal mucosa of pigs in radiofrequency hyperthermia. DESIGN, TIME AND SETTING: Observational study which was performed in the Department of Tumor, Affiliated Hospital of Luzhou Medical College from October 2004 to January 2005. MATERIALS: 13 pigs weighing 35-40 kg were used in this study. Esophagus stent of memory alloy with membrane was provided by Zhiye Medical Apparatus Institute of Changzhou, China METHODS: Five points were located for measurement, i.e. the middle of the stent, the exit of the stent, 2 cm and 4 cm a distance from the exit and 4 cm from the entrance. Esophagus of 13 pigs was heated for 30 minutes by SR-1000 radiofrequency hyperthermia machine in frequency of 40.82 MHz, pole plate of 25 cm Ⅱ 25 cm and power of 500-700 W. MAIN OUTCOME MEASURES: The esophageal mucosa was observed with naked eyes. And optical microscopy was used to observe the changes of the esophageal mucosa. RESULTS: Because one pig died of anesthesia and there were troubles of thermal detector lines in 4 pigs, only 8 pigs were included in the final analysis. Level of damage of esophageal mucosa on five temperature checkpoints was observed from grade 0 to 1 in naked eyes, and the difference of damaged level between five checkpoints was not obvious in statistics (H=2.0, P=0.157). Level of the damage was observed from grade 0 to 2 in microscope, and the difference was not obvious in statistics too (H=2.734, P=0.255). CONCLUSION: Influence of the metal stent on esophageal mucosa can be neglected in radiofrequency hyperthermia, and metal stent does not cause obvious mechanical damage or thermal damage to esophageal mucosa of pigs. It is safe and feasible to carry out radiofrequency hyperthermia on placed metal stent esophagus.关键词
射频热疗/金属支架/食管黏膜/猪分类
医药卫生引用本文复制引用
陈玉林,吴敬波,宿向东,谭燕琼,范娟,文庆莲,黄镇东..射频深部热疗中金属支架对猪食管黏膜的损伤[J].中国组织工程研究与临床康复,2008,12(44):8775-8778,4.
