首页|期刊导航|中华医学杂志（英文版）|Dose-effect relationships in total body irradiation on the healing of cutaneous wounds
中华医学杂志（英文版）2003，Vol.116Issue(6)：878-882,5.
Dose-effect relationships in total body irradiation on the healing of cutaneous wounds
Dose-effect relationships in total body irradiation on the healing of cutaneous wounds
摘要
Abstract
ObjectiveTo study the effects of dosages of total body irradiation on the healing process of cutaneous wounds and to observe the changes of wound area at different periods after injury.star rats. The single dosage varied from 1 to 8 Gy. Within 1 h after irradiation, two whole thickness circular cutaneduced on the back of the animals (combined injury groups). Same wounds were produced on rats with no irradiation (single wound group). Wound healing was observed at different points after injury. ResultsAfter total body irradiation with the dose of 1,2,3,4,5,6, 7 or 8 Gy, the wound healing was obviously retarded as the dosages increased. The wound area remained was larger in the large dosage groups than in the small dosage groups. Seven days after injury, there was 33.5% wound surface left unhealed in the single wound group, whereas in the combined injury groups, 35.4%, 38.1%, 41.6%, 48.8%, 53.9%, 63.7%, 69.2% and 73.9% of the wound surfaces remained unhealed, respectively. Statistical analysis showed marked correlations between the varioustimes after total body irradiation and various dosages to the percentage of unhealed wound surface. Nine dose-effect relation formulae were deduced according to the statistical results.ConclusionsIn soft tissue trauma combined with radiation injury, the delay of wound healingis related to the dose of radiation inflicted. It is also related to the time between injury and time of observation.关键词
irradiation/combined radiation-trauma injury/wound healing/dose-effectKey words
irradiation/combined radiation-trauma injury/wound healing/dose-effect分类
医药卫生引用本文复制引用
冉新泽,程天民,林远,屈纪富,刘都户,艾国平,阎国和,王文昌,许汝福..Dose-effect relationships in total body irradiation on the healing of cutaneous wounds[J].中华医学杂志（英文版）,2003,116(6):878-882,5.基金项目
This study was supported in part by the National Basic Research and Priorities Program (No. G1999054205). （No. G1999054205）
