动物学研究2007，Vol.28Issue(1)：88-94,7.
雌激素在脑缺血诱导的大鼠齿状回神经再生中的作用
Effects of Oestrogen on Ischemia-induced Neurogenesis in the Dentate Gyrus of Rats
摘要
Abstract
To study the effects of oestrogen on ischemia-induced neurogenesis in the hippocampal dentate gyrus, thirty-two adult male rats were randomly divided into four groups:the control surgery group with oestrogen administration (SE), the control surgery group with normal saline administration (SN), the middle cerebral artery occlusion (MCAO) group with oestrogen administration (ME) and the MCAO group with normal saline administration (MN). The MCAO rats were occluded for 90 min by an intraluminal filament and then recirculated. After 1, 3, 12, 24 and 28 h of MCAO, the rats of the four groups were killed to investigate the infarct volume, apoptosis and neurogenesis. The cerebral infarct volume in the ME group was significantly smaller than that of the MN group (P＜0.05). No significant cell loss was seen in the dentate gyrus. Cerebral ischemia led to increased neurogenesis, which is independent of cell death in the ipsilateral dentate gyrus(P＜0.05). BrdU-positive cells in the ipsilateral dentate gyrus of the ME group were significantly increased when compared with those of the MN group(P＜0.05). In the SE group, BrdU-positive cells in both the ipsilateral and contralateral dentate gyrus, were increased when compared with those of the SN group(P＜0.05). We concluded that oestrogen plays an important role in neurogenesis, which is independent of ischemia-induced by MCAO in the hippocampal dentate gyrus of rats.关键词
局灶性脑缺血/梗死体积/神经元再生/雌激素/细胞死亡/齿状回Key words
Cerebral ischemia/Infarct volume/Neurogenesis/Oestrogen/Cell death/Dentate gyrus分类
生物科学引用本文复制引用
王明,鲁亚平,朱国萍,张晓盼,韩莹,余中宾..雌激素在脑缺血诱导的大鼠齿状回神经再生中的作用[J].动物学研究,2007,28(1):88-94,7.基金项目
国家自然科学基金(30470537) （30470537）
安徽师范大学生命科学学院分子进化与生物多样性重点实验室开放基金 （）
安徽省教育厅自然科学基金重点项目(22005kj028zd) （22005kj028zd）
安徽省重点实验室科研基金项目资助(This work was supported by National Natural Science Foundation of China (30470537) （This work was supported by National Natural Science Foundation of China (30470537）
The Open Fundation from The Key Laboratory of Molecular Evolution and Biodiversity, College of Life Science, Anhui Normal University （）
Natural Science Foundation of Department of Education, Anhui Province (2005kj028zd) （2005kj028zd）
The Key Lab. Science Foundation of Anhui Province （）
