摘要
Abstract
Objective To study the surgical technique and results of laryngeal function preservation in treatment of hypopharyngeal carcinoma. Methods A retrospective review of 305 patients with malignant neoplasms of the hypopharynx (279 males, 26 females, age ranging from 14 to 77 years) was performed from 1978 to 1996. In the 305 patients (stage Ⅰ, n=6; stage Ⅱ, n=12; stage Ⅲ, n=82; stage Ⅳ, n=205), the sites of origin were pyriform sinus (n=234), postcricoid (n=21), posterior pharyngeal wall (n=35) and superior hypopharynx (n=15). Of the 305 patients, 206 (67.54%, stage Ⅰ, n=6; stage Ⅱ, n=12; stage Ⅲ, n=65; stage Ⅳ, n=123) were surgically treated with laryngeal function preserved and 99 (32.46%, stage Ⅲ, n=17; stage Ⅳ, n=82) had no laryngeal function preserved. All had 55-75 Gy radiotherapy according to their need. Results A total of 206 patients (67.54%) were surgically treated with laryngeal function preserved, totally (voice, respiration and deglutition) in 139 (67.5%) and partially (voice and deglutition) in 67 (32.5%). 99 patients (32.46%) had no laryngeal function preserved. The overall 5-year survival rate of the 305 patients was 44.8%, which segregated to 83% (stage Ⅰ), 71% (stage Ⅱ), 58% (stage Ⅲ), and 36% (stage Ⅳ). The 5-year survival of the laryngeal function preserved group was 48% (n=66), the rate of complications 28% (n=58) and the rate of residual tumor 5.8% (n=12), compared with the no laryngeal function preserved group 37% (n=20), 31.3% (n=31), and 6% (n=6) (P>0.05). Conclution Only a small proportion of patients (31/305, 10%) with hypopharyngeal carcinoma who require total laryngectomy and preservation of the laryngeal function is feasible for eradication of tumor and preservation of laryngeal function.关键词
下咽肿瘤/咽切除术/保留喉功能Key words
hypopharyngeal neoplasm/hypopharyngectomy/preservation of laryngeal function分类
医药卫生
