中国中西医结合杂志2001，Vol.21Issue(2)：90-93,4.
造血干细胞移植联合中医中药治疗恶性血液病12例
Twelve Cases of Malignant Hematopathy Treated by Combined Therapy of Hematopoietic Stem Cell Transplantation and Chinese Herbal Medicine
摘要
Abstract
Objective: To evaluate the effect of hematopoietic stem celltransplantation combined with Chinese herbal medicine in treating malignant hematopathy. Methods: Allo-bone marrow transplantation (Allo-BMT) or allo-peripheral blood stem cell transplantation (Allo－PBSCT), with conditioning regimen of TBI＋Cy or Bu ＋Cy, was used to treat 4 cases of chronic granulocytic leukemia (CGL, 3 of chronic phase and 1 of acceleration phase) and one case of acute non-lymphocytic leukemia (ANLL). And auto-BMT or auto-PBSCT, with conditioning regimen of MAC or MAC＋VP16, was used to treat 7 cases of hematopathy, including 5 cases of ANLL (3 of CR1 and 2 of CR2) and 2 cases of malignant lymphoma (1 of first occurring and 1 of relapse). Chinese herbal medicine was given orally to all the 12 patients after transplantation according to TCM Syndrome Differentiation. Results: All patients were successfully engrafted. Within the median follow-up period of 18 (4－70) months, one patient (8.3%) died of transplantation-related death, 3(25.0%) relapsed and 8 (66.7%) survived free of original disease. The transplantation effective rate was 88.8% as counting by ANLL CR1 and CGL chronic phase. Conclusion: Auto-BMT or auto-PBSCT in CR1 stage of acute leukemia could reduce the relapse rate, when there was no matched bone marrow donor; allo-BMT or allo-PBSCT in chronic stage could result in long-term disease-free survival of patients; Chinese herbal medicine administration in patients of malignant hematopathy might reduce the complications and plays certain role in promoting recovery of hematopoietic function.关键词
白血病/淋巴瘤/造血干细胞移植/中医中药分类
医药卫生引用本文复制引用
虞荣喜,周郁鸿,朱宁希,沈建平,胡致平,罗秀素,林圣云,沈一平,陈均法,孙洁..造血干细胞移植联合中医中药治疗恶性血液病12例[J].中国中西医结合杂志,2001,21(2):90-93,4.基金项目
浙江省中医管理局资助课题(No.9409) （No.9409）
