郧阳医学院学报2001，Vol.20Issue(1)：9-11,3.
CD68、CD43和肌动蛋白在实验性家兔动脉粥样硬化斑块中的表达
Expression of CD68、CD43 and Actin in Experimentally Atherosclerotic Plaques in Rabbits
杜兴贵 1胡承江 1易建华1
作者信息
- 1. 郧阳医学院病理教研室，湖北十堰 442000
- 折叠
摘要
Abstract
Objective To investigate the relationship between the origins offoam cell and the formation of the atherosclerotic plaques.Methods The expression of CD68,CD43 and actin were examined by immunohistochemical S-P method with monoclonal antibodies in aortic and coronary plaques of experimental atherosclerosis (including 62 fatty streak plaques and 38 fibrous plaques)in rabbits.Results The expression of CD68,CD43 and actin in aortic and coronary plaques was no remarkably different (P>0.05).The positive materials of CD68 were mostly diffuse distribution and the positive materials of CD43 were primarily central distribution in fatty streak plaques.The expression of CD68,CD43 in fatty streak plaques were remarkably higher than that in fibrous plaques (P<0.01).Actin in fibrous plaques were significantly higher than that in fatty streak plaques (P<0.01).Conclusions It is suggested that the foam cells of atherosclerosis originated mostly from macrophages in the streak plaques, and the origin of foam cell is mostly VSMC in fibrous plaques and it is related to formation of fibrous cap in atherosclerosis plaques.The interaction of T lymphocytes and macrophages,in locally infiltration may be a major element in fatty necrosis of plaques.关键词
CD68/CD43/肌动蛋白类/动脉粥样硬化/免疫组织化学Key words
CD68/CD43/actins/atherosclerosis/immunohistochemistry分类
医药卫生引用本文复制引用
杜兴贵,胡承江,易建华..CD68、CD43和肌动蛋白在实验性家兔动脉粥样硬化斑块中的表达[J].郧阳医学院学报,2001,20(1):9-11,3.
