华西医科大学学报2001，Vol.32Issue(1)：9-11,3.
心肌梗塞大鼠心室胶原生化改建与心脏肾素-血管紧张素系统的关系
Biochemical Remodeling of Myocardial Collagen and Its Relation to Car diac Renin-angiotensin System in Rats after Myocardial Infarction
摘要
Abstract
Objective This study aimed at the biochemical rem odeling ofmyocardial collage n and its relation to cardiac renin-angiotensin system (RAS) after myocardial i n farction(MI).Methods The ventricular and plasma angiotensin Ⅱ(Ang Ⅱ) content , total collagen content, and collagen concentration in left ventricle(LV) and right v entricle(RV) of MI and sham-operated control(SOC) rats on 3,15 and 42 days afte r operation were measured dynamically by means of radioimmunoassay etc. Results The plasma Ang Ⅱ content increased only in MI rats on day 3. The Ang Ⅱ content in LV of the MI group increased markedly on day 3 after MI as compared with that of the SOC group.It sustained at this higher level on the 15 th and 42th days,and the similar changes were observed in RV as well.The biochem ical remodeling of collagen in LV and RV occurred after MI and the remodeling of collagen showed similar patterns with its Ang Ⅱ content, except that collagen remodeling in RV was delayed than the change of Ang Ⅱ content.Conclus ion The cardiac RAS was obviously activated after MI. Ventricular Ang Ⅱ mi ght play an important role in the biochemical remodeling of myocardial collagen, and its role was independent of circulating RAS.关键词
血管紧张素Ⅱ/胶原/改建/心肌梗塞分类
医药卫生引用本文复制引用
黄英,雷立权,高广道,王树人,孙晓明..心肌梗塞大鼠心室胶原生化改建与心脏肾素-血管紧张素系统的关系[J].华西医科大学学报,2001,32(1):9-11,3.基金项目
国家"八五”攻关 （）
