中国临床康复2002，Vol.6Issue(6)：912，915,2.
通窍活血汤预防迟发性脑血管痉挛的实验研究
Experimental investigation on the prevention of delayed cerebral vasospasm with Tong Qiao Huo Xue Tang
熊家锐 1段传志 2王玉斌 1王庆宣 1成文平 3赵刚3
作者信息
- 1. 151th Hospital of PLA,Anyang 455000,China
- 2. Zhujiang Hospital,First Military Medical University,Guangzhou 510000,China
- 3. First Military Medical University, Guangzhou 510000,China
- 折叠
摘要
Abstract
Objective To investigate the prevention effects and the physicochemical mechanisms of action of Tong Qiao Huo Xue Tang on delayed cerebral vasospasm(DCD) after subarachnoid hemorrhage(SAH).Methods Macaca cynomolgus were divided into two groups and underwent craniectomy,a semipermeable microdialysis catheter was placed adjacent to right middle cerebral artery (MCA).Therapeutic group were exposed to Tong Qiao Huo Xue Tang and control group to placebo via oral .Results The diameter of proximal MCA in therapeutic group changed slightly on 7th day after operation(P >0.05),whereas it decreased prominently(P< 0.05) in control group with severe vasospasm.OxyHb concentration:There's no significant difference between the two groups on 2nd ～ 5th day(P >0.05),the concentration of therapeutic group(was zero after 8 days) was lower than that of control group (became zero after 12 days) on 6th ～ 8th day(P< 0.05).The peak value of therapeutic group (on 5th day) was lower than that of control group (on 7th day)(P< 0.05).Conclusion Tong Qiao Huo Xue Tang can prevent DCV after SAH effectively and decreasing OxyHb concentration around vessels after SAH maybe the mechanism.
关键词
subarachnoid hemorrhage/delayed cerebral vasospasm/Tong Qiao Huo Xue Tang/cerebral angiography/microdialysis
分类
医药卫生引用本文复制引用
熊家锐,段传志,王玉斌,王庆宣,成文平,赵刚..通窍活血汤预防迟发性脑血管痉挛的实验研究[J].中国临床康复,2002,6(6):912，915,2.
