中国现代医学杂志2004，Vol.14Issue(23)：9-13,5.
超声辐照对大鼠颈动脉损伤后早期c-jun,hsp70与BAX表达的影响
Effects of ultrasound exposure on expression of c-jun,hsp70 and BAX in carotid artery of rats early after balloon lesions
摘要
Abstract
Objective: To investigate the molecular mechanisms of the anti-restenosis effects of ultrasound exposure (USE). Methods: Balloon injured model of carotid artery of rats had been built with a 2F balloon catheter, then USE (705KHz, 1 w/cm2, 3 min) was applied. The expression of c-jun, hsp70 and BAX in the artery wall was detected by in situ hybridization (ISH) and Immunohistochemistry (IHC) 30 minutes and 4 hours after balloon lesions respectively. Results: The expression of c-jun and hsp70 mRNA in normal carotid artery increased significantly 30minutes after balloon lesions. There was no difference of c-jun mRNA expression between Balloon and Balloon+USE group (P =0.773), but the expression of hsp70 mRNA was significantly lower in the latter group (P ＜0.01). Results of the later IHC were similar with that of the ISH detection. The expression of BAX protein was significantly higher in Balloon+USE group than in Normal group (P ＜0.01) and Balloon group (P ＜0.05). USE alone couldn't change the expression of hsp70 and c-jun compared with Normal group. Conclusion: The anti-restenosis effects of the USE might be related to the changed expression of hsp70 and BAX in the damaged artery wall.关键词
动脉损伤/超声辐照/再狭窄/分子机制Key words
artery lesions/USE/restenosis/molecular mechanisms分类
医药卫生引用本文复制引用
唐艺加,黄晶,王新,张俊霞,唐海林,刘地川,邓昌明,刘光聪,吕基全..超声辐照对大鼠颈动脉损伤后早期c-jun,hsp70与BAX表达的影响[J].中国现代医学杂志,2004,14(23):9-13,5.基金项目
This study was founded by the National Natural Science Foundation of China (ratification code: 30040030) （ratification code: 30040030）
