中国肺癌杂志2001，Vol.4Issue(2)：91-93,3.
非小细胞肺癌微血管计数与血管内皮生长因子表达
Effects of vascular endothelial growth factor in the invasion and metastasis of non-small cell lung cancer
摘要
Abstract
Objective To study the effects of vascular endothelial growthfactor (VEGF) in the invasion and metastasis of non-small cell lung cancer (NSCLC). Methods The expression of VEGF and the microvascular count (MVC) were determined in 65 cases of NSCLC by immunohistochemistry method. Results The positive rate of VEGF expression was 83.1％(54／65) in 65 cases of NSCLC. The microvascular count in patients with metastasis was significantly higher than that without metastasis (58.90±31.45 vs 21.44±12.77，P＜0.01). The microvascular count in patients with stageⅠ-Ⅱ was significantly lower than that of stage Ⅲ disease(19.53±16.27 vs 60.24±28.29, P＜0.01). The positive rate of VEGF expression was remarkably higher in patients with metastasis(100％,44／44) and in stage Ⅲ disease (100％, 29／29) than that in patients without metastasis(47.6％, 10／21) and in stageⅠ-Ⅱ disease (69.4％, 25／36)(P＜0.01). VEGF expression was closely related to MVC, but not to histological types and the size of tumor (P＞0.05). Conclusion The results suggest that VEGF may play an important role in the invasion and metastasis of NSCLC, and detection of VEGF expression and MVC might be helpful to judge the metastasis of NSCLC and to predict the prognosis of patients with NSCLC.关键词
血管内皮生长因子/非小细胞肺癌/微血管计数分类
医药卫生引用本文复制引用
沈诚,范士志,蒋耀光,陈建明,李志平..非小细胞肺癌微血管计数与血管内皮生长因子表达[J].中国肺癌杂志,2001,4(2):91-93,3.基金项目
本研究受重庆市科委应用基础基金(No.995658)资助 （No.995658）
