肿瘤防治研究2001，Vol.28Issue(2)：92-93,114,3.
人肝细胞癌静脉癌栓形成与CD44V6和PCNA表达的研究
Relationship of CD44V6 and PCNA Expression with Tumor Thrombus Forming in Human Hepatocellular Carcinoma
马捷 1周晓军 1张泰和 1孙桂勤 1孟奎1
作者信息
摘要
Abstract
Objective To study the relationship of CD44V6 and PCNA expressionwith tumor thrombus forming in human hepatocellular carcinima (HCC).Methods 30 cases of HCC with corresponding noncancerous tissues,6 cases of normal liver tissues were stained with CD44V6 and PCNA by immunohistochemical method.Semiquantitation of CD44V6 and PCNA were studied and analyzed with clinico-pathological features of HCC.Results 12/30 of HCC tissues showed CD44V6 expression with membranous staining.CD44V6 expression in HCC with tumor thrombus forming was 5/6 with high PCNA expression.There were statistic difference between HCC with tumor thrombus and HCC without tumor thrombus in CD44V6(P<0.01) and PCNA(P<0.05) expression.CD44V6 expression was also related with tumor grade and PCNA expression in HCC.Conclusion The CD44V6 expression in HCC cells is related to their tendency to invade vessels and may have implication for metastatic potential and prognosis.关键词
肝细胞癌/血管浸润/CD44V6/PCNA分类
医药卫生引用本文复制引用
马捷,周晓军,张泰和,孙桂勤,孟奎..人肝细胞癌静脉癌栓形成与CD44V6和PCNA表达的研究[J].肿瘤防治研究,2001,28(2):92-93,114,3.
