中国免疫学杂志2001，Vol.17Issue(2)：93-95,3.
外源性LIF和IL-1对围着床期小鼠子宫内膜整合素β3亚基表达的调节
Regulation of external LIF on the expression of integrin β3 in the mouse endo metrium during peri-implantation period
摘要
Abstract
Objective:To study regulation of external leukemia inhibitory factor(LIF) and interlukin- 1(IL-1) on the expression of integrin β3 in the mouse endometrium during per i-implantation period and explore the mechanism which LIF participate in embryo ni c implantation.Methods:The mice were injected peritoneally with LIF,IL-1 or IL-1ra at different administration on day 2～4 of pregnancy .The level of integrin β3 protein was measured with Westernblot method and mR NA measured with RT-PCR.Results:The levels of integrin β 3 protein and mRNA were increased by LIF and IL-1(P＜0.05) and which reli ed o n administration.The level of integrin β3 mRNA was decreased by IL-1ra (P <0.05).Conclusion:LIF and IL-1 of cytokines can improve the expr ession of integrin β3 in the peri-implantation endometrium of mouse.Both of them may take part in implantation by regulating cell adhesion molecules.关键词
白血病抑制因子/白介素-1/整合素β3亚基/子宫内膜/着床分类
医药卫生引用本文复制引用
张炜,周剑萍,刘银坤,朱瑾..外源性LIF和IL-1对围着床期小鼠子宫内膜整合素β3亚基表达的调节[J].中国免疫学杂志,2001,17(2):93-95,3.基金项目
本课题受上海市卫生局科技基金资助(96429) （96429）
