临床与实验病理学杂志2001，Vol.17Issue(2)：93-98,6.
EB病毒相关与不相关的肠道T细胞淋巴瘤临床病理研究
Epstein-Barr virus-associated and Epstein-Barr virus not-associated intestinal T-cell lymphomas:A clinicopathologic study
张文燕 1李甘地 1刘卫平 1任兴昌 1李俸媛 1张尚福1
作者信息
摘要
Abstract
Purpose To investigate the clinicopathological and immunohistochemical features of Epstein-Barr virus-associated and Epstein-Barr virus not-associated primary intestinal T-cell lymphomas(ITCL) and to study their cell origins. Methods In situ hybridization for EBER1/2 and immunohistochemical staining for immunophenotypes, LMP-1,TIA-1,bcl-2 and CD21 were performed in 32 cases. The clinical data were analyzed and all patients were followed-up. Results (1) In 27 of the 32 cases, EBER1/2 were detected in the tumor cells, in which 11 presented LMP-1 positive reactions. (2) All 32 cases of ITCL revealed CD45RO positivity，in which 4（12.5%） expressed CD8，8（25.0%）expressed CD4, 9（28.1%）expressed CD56,and 31（96.9%）expressed TIA-1. There were 17（53.7%）cases with CD4-，CD8-，CD56- immunophenotype. None expressed bcl-2 and CD21. 32 ITCL were classified into pleomorphic medium and large cell(n=28), monomorphic medium-sized(n=2), pleomorphic small cell(n=2). Clinically, most patients with ITCL were young males with abdominal pain, hematochezia, fever and weight loss. The prognosis of patients with ITCL showed poor (survival median was 1.7 month). (3) The differences between EBV-associated and EBV not-associated ITCL lay in hematochezia, fever and the expression of CD3, CD8 and CD56. Conclusion Most of Chinese ITCL are EBV-associated ones with unusual clinicopathological and immunohistochemical features，which are of different lineages of T-cell subtypes, including cytotoxic T-cell or NK cell.关键词
肠肿瘤/淋巴瘤,T细胞/EB病毒/免疫表型分型分类
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张文燕,李甘地,刘卫平,任兴昌,李俸媛,张尚福..EB病毒相关与不相关的肠道T细胞淋巴瘤临床病理研究[J].临床与实验病理学杂志,2001,17(2):93-98,6.
