摘要
Abstract
The aim of the present study was to compare the effects of hypoxia on NO,ET-1 and NO/ET-1levels in Wistar rats and pikas. We determined NO and ET-1levels in the serum of 30 rats (three groups of 10 rats, each taken to 3 780 m and divided into 24 h, 2 wk and 3 wk durations) and 10 pikas at 3 780 m by ELISA and Nitrate Reductase Method. We compared the values of NO, ET-1 and NO/ET-1 in rats of 24 h duration with those in rats of 2 wk and 3 wk durations.We then compared NO, ET-1 and NO/ET-1 values in the 24 h, 2 wk, 3 wk groups with those in pikas. In the beginning of entry to high altitude, the NO and ET-1levels in rats were markedly increased compared to those in pikas (respectively, P＜0.01), whereas the values of NO/ET-1in rats and pikas were very close (P＞0.05). There was a decreasing trend in NO levels and an increasing trend in ET-1levels (respectively, P＜0.01) with passage of time at high altitude in rats, and NO was well correlated with ET-1(r2=0.2416, P＜0.01). The NO/ET-1levels in pikas was approximately 2 fold greater than in the 2 wk and 3 wk groups (P＜0.01). In conclusion, NO,ET-1and NO/ET-1levles in Wistar rats and pikas at 3 780 m are very different, may indicate adaption or acclimitization to high altitude hypoxia.关键词
高原鼠兔/Wistar大鼠/一氧化氮(NO)/内皮素-1(ET-1)Key words
Endothelin-1(ET-1)/Hypoxia rat/Nitric oxide (NO)/Pika分类
生物科学
