中国药理学与毒理学杂志2008，Vol.22Issue(2)：95-101,7.
醋酸艾塞那肽在大鼠体内的代谢分布
Tissue distribution of exendin-4 in rats
摘要
Abstract
AIM To investigate the tissue distribution of exendin-4 after administration in healthy rats. METHODS Exendin-4 was radioiodinated by the Iodo-GenTMmethod. Tissue distribution of [125I]exendin-4 was investigated after sc administration of [125I]exendin-4 at 3 μg·kg-1 in rats. Both total radioactivity and trichloroacetic acid (TCA) precipitated radioactivity were used to calculate the levels of [125I]exendin-4 in rats plasma and tissue samples after sc administration. RESULTS The tissue distribution of [125I]exendin-4 after sc injection showed substantial disposition in kidneys, lungs, bladder and pancreas. The rank order of normalized tissue distribution was kidneys＞lungs＞bladder＞pancreas＞intestine＞plasma＞adrenals>jejunum＞lymph＞liver＞spleen＞heart＞marrow＞thymus＞testicles＞brain＞muscle＞adipose. CONCLUSION [125I]Exendin-4 underwent a rapid and wide distribution in the tissues throughout the whole body within the time course examined. TCA precipitated radioactivity in kidneys was the highest, however, only trace amounts of [125I]exendin-4 was detected in the brain.关键词
醋酸艾塞那肽/组织分布/ 药代动力学Key words
exendin-4/ tissue distribution/ pharmacokinetics分类
医药卫生引用本文复制引用
艾国,陈知航,单成启,车津晶,候禹男,程远国..醋酸艾塞那肽在大鼠体内的代谢分布[J].中国药理学与毒理学杂志,2008,22(2):95-101,7.基金项目
The project supported by National High Technology Research and Development Program of China (2003AA2Z347B) （2003AA2Z347B）
国家高技术研究发展计划资助项目(2003AA2Z347B) （2003AA2Z347B）
