现代妇产科进展2006，Vol.15Issue(12)：957-960,4.
Expression and clinical significance of dendritic cell and transforming growth factor-beta 1 in cervical cancer
Expression and clinical significance of dendritic cell and transforming growth factor-beta 1 in cervical cancer
Zhao 1Shan 2Rong 3Fengnian3
作者信息
- 1. Department of Obstetrics and Gynecology,Shandong University,Shandong Qianfoshan Hospital,Jinan 250014
- 2. Department of Obstetrics and Gynecology,Shandong Qianfoshan Hospital
- 折叠
摘要
Abstract
Objective:To explore the density and mature status of Dendritic cell(DC) in cervical cancer and correlation with the expression of transforming growth factor-beta 1(TGF-β1).Methods:Streptavidin-peroxidase(SP) immunohistochemistry methods were used to detect S-100 DC and the expression of TGF-β1 in 20 normal cervical tissues and 53 cervical cancer tissues without any sort of chemotherapy or radiation therapy prior to resection.Medical records were reviewed,clinicopathological variables were retrieved and used for analysis.Results:Two types of DC were observed under the microscope.The expression of DC in cervical cancer was significantly higher than that in normal tissues(23.34 cells/mm2 vs 29.91 cells/mm2,P＜0.05),and significantly higher in early stage than that in advanced stage(P＜0.05).The expression of TGF-β1 was significantly higher in cervical cancer than that in normal tissues (P＜0.025).However,there was no correaction between TGF-β1 and lymph nodes metastasis.The index of DC in cervical cancer was negatively correlated to the expression of TGF-β1 in tumor cells (r=-0.8875,P=0.0001).Conclusion:Maturation of DC in cervical cancer is inhibited.The decreased number of DC and the higher expression of TGF-β1 are due to the failure of the immunity,these may play an important role in the development of the cervical cancer.关键词
Cervical neoplasms/Dendritic cells/Transforming growth factor-beta/ImmunosuppressionKey words
Cervical neoplasms/Dendritic cells/Transforming growth factor-beta/Immunosuppression分类
医药卫生引用本文复制引用
Zhao,Shan,Rong,Fengnian..Expression and clinical significance of dendritic cell and transforming growth factor-beta 1 in cervical cancer[J].现代妇产科进展,2006,15(12):957-960,4.
