南京医科大学学报（英文版）2005，Vol.19Issue(2)：95-98,4.
Mutations in the D-loop region of mitochondrial DNA in gastric cancer
Mutations in the D-loop region of mitochondrial DNA in gastric cancer
Yibing Zhao 1Hongyu Yang 1Guoyu Chen1
作者信息
- 1. Department of Gastrointestinal Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
- 折叠
摘要
Abstract
Objective: To investigate the mutations in the D-loop region of mitochondrial DNA (mtDNA) in gastric cancer.Methods: The mtDNA of D-loop region was amplified by PCR and sequenced in 20 samples from gastric cancer tissue and adjacent normal membrane. Results: There were 7/20(35% ) mutations in the mtDNA of D-loop region in gastric cancer patients. There were four microsatellite instabilities among the 18 mutations. Nine new polymorphisms were identified in 20 patients. Conclusion: The mtDNA of Dloop region might be highly polymorphoric and the mutation rate is high in patients with gastric cancer.关键词
mitochondrial DNA/D-loop/mutationKey words
mitochondrial DNA/D-loop/mutation引用本文复制引用
Yibing Zhao,Hongyu Yang,Guoyu Chen..Mutations in the D-loop region of mitochondrial DNA in gastric cancer[J].南京医科大学学报（英文版）,2005,19(2):95-98,4.
