中德临床肿瘤学杂志（英文版）2003，Vol.2Issue(2)：95-98,4.
EGFR、C-erbB-2在乳腺癌组织中的表达及其与乳腺癌骨髓微小转移的关系
Expression of EGFR, C-erbB-2 Proteins in Breast Cancer and Their Relation with Micrometastasis in Bone Marrow
武正炎 1郑伟1
作者信息
- 1. 南京医科大学第一附属医院普外科,210029
- 折叠
摘要
Abstract
Objective To investigate the expression of epidermal growth factor receptor and C-erbB-2 proteins in breast cancer, and their relation with micrometastasis in bone marrow.Methods SABC immunocytochemical assay for EGFR and C-erbB-2 proteins were made on paraffin embedded sections. The statistical analyses were performed using chi-square test.Results Overall, 42.9% of the tumors were EGFR positive. C-erbB-2 were positive in 31% of the tumors. The positivity of both EGFR, C-erbB-2 was significantly correlated with that of micrometastasis in bone marrow. The positivity of EGFR was not related to that of C-erbB-2. The follow-up period was 60 months. The overall survival was worse in patients with EGFR, C-erbB-2 positive tumors than EGFR, C-erbB-2 negative tumors.Conclusion EGFR, C-erbB-2 proteins are significantly related to micrometastasis in bone marrow. Multivariate analyses show that both EGFR and C-erbB-2 proteins are two key prognostic factors in breast cancer patients.关键词
乳腺癌/表皮生长因子受体/C-erbB-2/骨髓微小转移Key words
breast neoplasm/epidermal growth factor receptor/C-erbB-2/bone marrow micrometastasis分类
医药卫生引用本文复制引用
武正炎,郑伟..EGFR、C-erbB-2在乳腺癌组织中的表达及其与乳腺癌骨髓微小转移的关系[J].中德临床肿瘤学杂志（英文版）,2003,2(2):95-98,4.
