生殖医学杂志2001，Vol.10Issue(2)：95-98,4.
正常月经周期中内皮素变化规律的研究
A study on the variation of endothelin levels during normal menstrual cycle
摘要
Abstract
Objective: To investigate the variation of plasmic and endometrial endothelin levels in healthy fertile women during normal menstrual cycle. To determine the relationship between levels of endothelin and concentrations of serum estradiol and progesterone.
Methods: Blood samples were obtained on four occasions throughout the normal menstrual cycle (early-proliferative phase, mid-proliferative phase, mid-secretory phase and late-secretory phase)from 38 normally menstruating women. Plasmic endothelin, estradiol and progesterone were measured by radioimmunoassay. 27 women agreed to have an endometrial biopsy taken for evaluation of endometrial endothelin level at one occasion together with blood sampling.
Results: There were no significant differences of plasmic endothelin levels in different phases of normal menstrual cycle. There was no correlation between plasmic endothelin and estradiol or progesterone. In contrast, endometrial endothelin concentrations varied in different phases of the menstrual cycle. The levels of endometrial endothelin in proliferative phase were significant lower than those in secretory phase (2.76±1.25 pg/mg, 3.90±1.30 pg/mg respectively, P<0.05). No correlation was found between endometrial endothelin and ovarian steroid concentrations.
Conclusion: Endometrial ET might play an important role in the onset of menstruation and in regulating of uterine bleeding.关键词
内皮素/月经周期分类
医药卫生引用本文复制引用
王清,韩丽晖,范慧民,董源芬..正常月经周期中内皮素变化规律的研究[J].生殖医学杂志,2001,10(2):95-98,4.
