华中师范大学学报（自然科学版）2002，Vol.36Issue(1)：96-102,7.
疟疾疫苗的研究策略
Study on malaria vaccines
摘要
Abstract
This paper describes the major strategies that have been employed in malaria vaccine development. The pre-erythrocytic-stage vaccines aim to prevent the development of all clinical symptoms and subsequent malaria transmission. Erythrocytic-stage vaccine designed aims to induce antibodies that prevent invasion and infection of erythrocytes, to reduce morbidity and mortality by decreasing the parasite load. Sexual-stage 'transmission blocking' vaccines aim to reduce malaria within a community as a whole, but convey no benefit for a malaria-infected individual. The design of a malaria vaccine must overcome genetic restriction to be effective to a diverse population. Due to the complex nature of the malaria life-cycle, it points out multiple antigens from different stages must also be incorporated into a vaccine.关键词
疫苗/疟疾/红细胞前期/红细胞期/策略Key words
vaccine/malaria/pre-erythrocytic-stage/erythrocytic-stage/strategy分类
医药卫生引用本文复制引用
杨其仁,陈思祗..疟疾疫苗的研究策略[J].华中师范大学学报（自然科学版）,2002,36(1):96-102,7.基金项目
Supported by China Scholarship Council,Ministry of Education of People's Republic of China(97842002). （97842002）
