中国组织工程研究与临床康复2007，Vol.11Issue(47)：9617-9620,4.
血管内皮祖细胞在人工血管移植后内皮化中的作用及其机制
Roles and mechanisms of endothelial progenitor cells in the post-transplant tacho-endothelialization of vascular prosthesis
李杰 1吕伟明 1李晓曦1
作者信息
- 1. 中山大学第一附属医院血管外科,广东省广州市,510080
- 折叠
摘要
Abstract
OBJECTIVE:To review the relationship between endothelial progenitor cells and the re-endothelialization of vascular prosthesis in order to find out some effective ways to solve the most frequent complications of asotransplantation,thrombogenesis and intima hyperplasia.DATA SOURCES:A computer-based online search was conducted to identify articles related to endothelial progenitor cells and the re-endothelialization of vascular prosthesis published in Pubmed,Ovid and MD Consult database from January 2000 to December 2006 using the key words of "endothelial progenitor cells,vascular prosthesis,endothelialization".Meanwhile,CNKI database was searched for related papers published between January 2000and December 2006,the keywords were "endothelial progenitor cells,vascular prosthesis,endothelialization" in Chinese.STUDY SELECTION:The literatures included all the related papers about the roles of endothelial progenitor cells in the re-endothelialization of vascular prosthesis.Inclusive criteria:the study types were randomized controlled trials,drug stress test and clinical drug effect test; the samples were both human and animals.Exclusive criteria:Reviews and literatures without controls were excluded.DATA EXTRACTION:Totally 115 related literatures were collected,and 24 were accorded with the inclusive criteria.The excluded were 91 papers of reviews and repeated trials or drug effect studies.DATA SYNTHESIS:These related literatures,including not only animal experiments but also clinical detections,analyzed the relationship between endothelial progenitor cells and the re-endothelialization of vascular prosthesis and correlative promoting mechanisms.CONCLUSION:It is concluded that endothelial progenitor cells play an important role in the endothelialization after vascular prosthesis is grafted in vivo.关键词
血管内皮祖细胞/人工血管/内皮化分类
医药卫生引用本文复制引用
李杰,吕伟明,李晓曦..血管内皮祖细胞在人工血管移植后内皮化中的作用及其机制[J].中国组织工程研究与临床康复,2007,11(47):9617-9620,4.
