中华医学杂志（英文版）2008，Vol.121Issue(11)：963-967,5.
Transplantation of autologous bone marrow mononuclear cells for patients with lower limb ischemia
Transplantation of autologous bone marrow mononuclear cells for patients with lower limb ischemia
GU Yong-quan 1LI Xue-feng 2YU Heng-xi 2CUI Shi-jun 2WANG Zhong-gao 2ZHANG Jian 2GUO Lian-rui 2QI Li-xing 2ZHANG Shu-wen 2XU Juan 2LI Jian-xin 2LUO Tao 2JI Bing-xin2
作者信息
- 1. Department of Vascular Surgery,Xuanwu Hospital,Institute of Vascular Surgery,Capital Medical University,Beijing 100053,China
- 2. Department of Vascular Surgery,Xuanwu Hospital.Institute of Vascular Surgery,Capital Medical University,Beijing 100053.China
- 折叠
摘要
Abstract
Background Many treatment options for lower limb ischemia are difficult to apply for the patients with poor arterial outflow or with poor general conditions.The effect of medical treatment alone is far from ideal.especially in patients with diabetic foot.A high level amputation is inevitable in these patients.This study aimed to explore the effect of transplantation of autologous bone marrow mononuclear cells on the treatment of lower limb ischemia and to compare the effect of intra-artedal transplantation with that of intra-muscular transplantation.Methods In this clinical trial,32 patients with lower limb ischemia were divided into two groups.Group 1 (16 patients with 18 affected limbs) received transplantation of autologous bone marrow mononuclear cells by intra-muscular injection into the affected limbs;and group 2(16 patients with 17 affected limbs)received transplantation of autologous bone marrow mononucJear cells by intra-arterial injection into the affected limbs.Rest pain,coldness,ankle/brachial index (ABI),claudication,transcutaneous oxygen pressure(tcPO2)and angiography(15 limbs of 14 patients)were evaluated before and after the mononuclear cell transplantation to determine the effect of the treatment.Results Two patients died from heart failure.The improvement of rest pain was seen in 76.5%(13/17)of group 1 and 93.3%(14/15)of group 2.The improvement of coldness was 100%in both groups.The increase of ABI was 44.4%(8/18)in group 1 and 41.2%(7,17)in group 2.The value of tcPO2 increased to 20 mmHg or more in 20 limbs.Nine of 15 limbs which underwent angiography showed rich collaterals.Limb salvage rate was 83.3%(15,18)in group 1 and 94.1%(16/17)in group 2.There was no statistically significant difference in the effectiveness of the treatment between the two groups.Conclusions Transplantation of autologous bone marrow mononucJear cells is a simple,safe and effective method for the treatment of lower limb ischemia,and the two approaches for the implantation,intra-muscular injection and intra-arterial injection,show similar results.关键词
autologous bone marrow/mononuclear cells transplantation/ischemia/legKey words
autologous bone marrow/mononuclear cells transplantation/ischemia/leg分类
医药卫生引用本文复制引用
GU Yong-quan,LI Xue-feng,YU Heng-xi,CUI Shi-jun ,WANG Zhong-gao,ZHANG Jian,GUO Lian-rui,QI Li-xing,ZHANG Shu-wen,XU Juan,LI Jian-xin,LUO Tao,JI Bing-xin..Transplantation of autologous bone marrow mononuclear cells for patients with lower limb ischemia[J].中华医学杂志（英文版）,2008,121(11):963-967,5.
