中国医科大学学报2001，Vol.30Issue(2)：96-97,2.
鼠缺血脑组织中Fas 抗原表达及细胞凋亡的动态研究
Dynamic Study of Fas Expression and Cell Apoptosis in the Cerebral Ischemic Tissues
罗晓光 1肖莉 2朱明 3曲恒春 4聂莹雪 1姜新 5李绍英 1张朝东1
作者信息
- 1. 中国医科大学第一临床学院神经内科,
- 2. 沈阳市急救中心
- 3. 辽中县胸科医院
- 4. 中国医科大学第一临床学院胸科实验室
- 5. 辽宁省人民医院神经内科
- 折叠
摘要
Abstract
Objective: Our purpose was to study the relationship between the Fas antigen expression and neuron apoptosis after cerebral ischemia. Methods: We detected the Fas antigen expression and neuron apoptosis dynamically in the animal models with cerebral ischemia by immunohistochemistry and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) method. Results: Fas antigen was positive after 30 minutes of ischemia and reached peak at 60 minutes. At the 24th hour, it began to decrease, and negative on the 3th day. While the positive cell for TUNEL method appeared after 60 minutes of ischemia, reached peak on 3 day, and decreased on 7 day. Conclusion: Neuron apoptosis after cerebral ischemia is closely related to the over-expression of Fas antigen.关键词
脑缺血/Fas抗原/凋亡分类
医药卫生引用本文复制引用
罗晓光,肖莉,朱明,曲恒春,聂莹雪,姜新,李绍英,张朝东..鼠缺血脑组织中Fas 抗原表达及细胞凋亡的动态研究[J].中国医科大学学报,2001,30(2):96-97,2.
